May 5, 2014
February 20, 2019

HIV Pathogenesis in 3D

HIV attaches to host CD4+ cell receptors and CCR5/CXCR4 via GP120. GP41 then fuses membranes allowing HIV to uncoat and empty it’s contents into the host cell. Once inside the cell HIV uses it’s reverse transcriptase to turn it’s RNA into DNA. This DNA then enters the nucleus and is then integrated into the host DNA via integrase. Using the hosts machinery HIV is transcribed back into RNA and sent out of the nucleus. Part of the RNA is translated and using protease undergoes proteolysis into HIV machinery. The other part is used as the HIV genome. Both the machinery (like reverse transcriptase and integrase) and the new RNA genome is then repackaged into cells and released to infect more cells.

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