Autoimmune Blistering
March 1, 2019
March 13, 2019

Whipple Disease

Whipple Disease – Tropheryma whippelii

Whipple Disease is an infectious enterocolitis that causes malabsorption in the small intestine. Tropheryma whippelii is a gram positive, rod-shaped actinomycete that causes symptoms when they accumulate within the macrophages of the small intestine lamina propria and block the mesenteric lymphatics. These foamy macrophages can sometimes be found within the synovium of joints, cardiac valves, and even the brain. Be sure you can identify this organism by presentation as well as it’s histology.

Look for PAS + rods within foamy macrophages that cause C.A.N.

Classic Symptoms 

  • Cardiac valves abnormalities
  • Arthralgias
  • Neurologic Dysfunction

Additional Symptoms

  • Diarrhea
  • Adenopathy
  • Fever
  • Weight Loss
  • Arthritis

Use the mnemonic!

PAS the CAN of FOAMY WHIPP cream


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