Examples include Nateglinide & Repaglinide
Meglitinides close K+ channels and cause the membrane to depolarize, in turn enhancing insulin release.
Meglitinides work by binding and closing K+ ATP channels in pancreatic beta cells. This results in membrane depolarization that enhances the release of insulin. With a rapid onset and short duration these drugs are taken with meals to reduce postprandial hyperglycemia, especially in persons allergic to sulfonylureas. Risk of hypoglycemia may be less than the risk with sulfonylureas.